Endoplasmic reticulum stress perpetuated toll-like receptor signalling-mediated inflammation in rheumatoid arthritis via X-box-binding protein-1.

ER stress arm XBP1s plays a pivotal role in proteasome inhibition-induced bone formation.Is there a relationship between early pregnancy loss and maternal serum human X-box binding protein 1 level? Uzun A, et al.Endoplasmic reticulum stress exacerbates inflammation in chronic rhinosinusitis with nasal polyps via the transcription factor XBP1.A novel XBP1 variant is highly enriched in cancer tissues and is specifically required for cancer cell survival.Expression Ubiquitous expression in salivary gland (RPKM 196.1), urinary bladder (RPKM 191.7) and 25 other tissues See more Orthologs mouse all NEW Try the new Gene table A pseudogene of XBP1 has been identified and localized to chromosome 5. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. Database of Single Nucleotide Polymorphisms (dbSNP)ДЇull Name X-box binding protein 1 provided by HGNC Primary source HGNC:HGNC:12801 See related Ensembl:ENSG00000100219 MIM:194355 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Also known as XBP2 TREB5 XBP-1 TREB-5 Summary This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box.Database of Genomic Structural Variation (dbVar).Online Mendelian Inheritance in Man (OMIM).Database of Genotypes and Phenotypes (dbGaP).Structure (Molecular Modeling Database).Conserved Domain Search Service (CD Search).BLAST (Basic Local Alignment Search Tool).

Hcc edem